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Craniofacial translational research based on molecular craniofacial developmental research

Overview

Leader Ichiro Takahashi, Kyushu Univeristy
Researcher Kazuaki Nonaka, Yoshihide Mori, Fumie Terao
Term April 2012 - March 2013
Research Outline

 Because the inborn specific abnormality that the phenotype appears in a face and the oral cavity affects chewing, speech, breathing as well as swallowing function, a life support function of the patient. The specific and strange feature of craniofacial anomaly in the face affects a socio-psychological activity leading the decline of patients’ quality of life remarkably. The cleft lip and/or palate (CLP) that are representative inborn specific abnormality present a phenotype on face. The incidence rate of CLP ranges from one of 500 births to one of 700 births in the world.
 In the present project, we elucidate mechanism of the outbreak of various kinds of inborn abnormality to show the phenotype in face, oral cavity including a CLP and aim at developing the oral function foundation therapy that we applied a bone reproduction therapy.
 We carry out translational research to develop the reproduction therapy of the bone defect with the cleft lip and/or cleft palate that using carbonate apatite and/or other materials as bone substitution materials, subsequently to accomplish the basic study of the molecular developmental biology in this study, and to elucidate molecules base of a chin face particularly lips and palate or the development of tooth. By these, I supplement findings each other and make use of the result of the basic study in translational research and build up a process of the development that is reciprocal exchange elucidating a problem in translational research by the study of the basic researches.

Report

Leader Ichiro Takahashi, Kyushu Univeristy
Researcher Kazuaki Nonaka, Yoshihide Mori, Fumie Terao
Term April 2012 - March 2013
Achievements Outline

 Because the inborn specific abnormality that the phenotype appears in a face and the oral cavity affects chewing, speech, breathing as well as swallowing function, a life support function of the patient. The specific and strange feature of craniofacial anomaly in the face affects a socio-psychological activity leading the reduction of patients’ quality of life remarkably. In this study, we elucidate mechanism of the outbreak of various kinds of inborn abnormality to show the phenotype in face, oral cavity including a cleft lip and/or cleft palate and aim at developing the oral cavity function foundation therapy that we applied a bone reproduction therapy. We have held a seminar and research meeting to establish close relationship among the researchers.
 We have held a seminar to introduce our research achievement and future prospects in the craniofacial biology research and regenerative research during USJI week in September 2013, and the meeting with researchers in the National Institute of Dental and Craniofacial Research/National Institutes of Health, DHHS, USA.

Activity Contents

USJI seminar:
Venue: Board Room, The Embassy Row Hotel, Washington DC,
Date: Monday September 10, 2012,
Event title: Craniofacial Translational Research Based on Molecular Craniofacial Developmental Research
Operating Adviser, USJI Ichiro Takahashi, Kyushu University,
Speakers:Kazuaki Nonaka, Kyushu University Faculty of Dental Science; Dr. Lillian Shum, Chief, NIHDCR/NIH; Haruyoshi Yamaza, Kyushu University Faculty of Dental Science
Publications
1. Ma L, Makino Y, Yamaza H, Akiyama K, Hoshino Y, Song G, Kukita T, Nonaka K,Shi S, Yamaza T. Cryopreserved dental pulp tissues of exfoliated deciduous teeth is a feasible stem cell resource for regenerative medicine. PLoS One. 2012;7 (12): e51777.
2. Fang J, Uchiumi T, Yagi M, Matsumoto S, Amamoto R, Takazaki S, Yamaza H,Nonaka K, Kang D. Dihydroorotate dehydrogenase is physically associated with the respiratory complex and its loss leads to mitochondrial dysfunction. Biosci Rep. 2012 Dec 7. [Epub ahead of print]
3. Ookuma YF, Kiyoshima T, Kobayashi I, Nagata K, Wada H, Fujiwara H, Yamaza H,Nonaka K, Sakai H. Multiple functional involvement of thymosin beta-4 in toothgerm development. Histochem Cell Biol. 2013 Feb;139(2):355-70.
4. Fang J, Uchiumi T, Yagi M, Matsumoto S, Amamoto R, Saito T, Takazaki S, Kanki T, Yamaza H, Nonaka K, Kang D. Protein instability and functional defects caused by mutations of dihydro-orotate dehydrogenase in Miller syndrome patients. Biosci Rep. 2012 Dec;32(6):631-9.
5. Mizokami A, Yasutake Y, Gao J, Matsuda M, Takahashi I, Takeuchi H, Hirata M. Osteocalcin induces release of glucagon-like peptide-1 and thereby stimulates insulin secretion in mice. PLoS One. 2013;8(2):e57375.
6. Ioi H, Kang S, Shimomura T, Kim SS, Park SB, Son WS, Takahashi I. Effects of buccal corridors on smile esthetics in Japanese and Korean orthodontists and orthodontic patients. Am J Orthod Dentofacial Orthop. 2012 Oct;142(4):459-65.
7. Yoshihara M, Terajima M, Yanagita N, Hyakutake H, Kanomi R, Kitahara T, Takahashi I. Three-dimensional analysis of the pharyngeal airway morphology in growing Japanese girls with and without cleft lip and palate. Am J Orthod Dentofacial Orthop. 2012 Apr;141(4 Suppl):S92-101.

Relative URL(s)

http://www.us-jpri.org/en/week/sep2012#event4

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