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Dentofacial translational research based on molecular craniofacial developmental research

Overview

Leader Ichiro Takahashi, Kyushu Univerisity
Researcher Kazuaki Nonaka, Yoshihide Mori, Naoto Haruyama, Haruyoshi Yamaza, Fumie Terao, (Kyushu Univeristy)
Term April 2013 - March 2014
Research Outline

 Because the inborn specific abnormality that the phenotype appears in a face and the oral cavity affects chewing, speech, breathing as well as swallowing function, a life support function of the patient. The specific and strange feature of craniofacial anomaly in the face affects a socio-psychological activity leading the reduction of patients’ quality of life remarkably. The cleft lip and/or cleft palate that are representative inborn specific abnormality show a phenotype on face. The occurrence rate ranges from one of 500 births to one of 700 births in the world.
 In this study, we elucidate mechanism of the outbreak of various kinds of inborn abnormality to show the phenotype in face, oral cavity including a cleft lip and/or cleft palate (CLP) and aim at developing the oral cavity function foundation therapy that we applied a bone reproduction therapy.
 We carry out translational research to develop the reproduction therapy of the bone defect with the cleft lip and/or cleft palate that used carbonic acid apatite as bone substitution materials, subsequently to accomplish the basic study of the molecular developmental biology in this study, and to elucidate molecules base of a chin face particularly lips and palate or the development of tooth. By these, I supplement findings each other and make use of the result of the basic study in translational research and build up a process of the development that is reciprocal exchange elucidating a problem in translational research by the study of the base.
 Prof. Mori in the present project has been visiting Vietnam to support surgical treatment of CLP patients every year. However, CLP specific malocclusion occurs after the surgery worsens with the development of the children, which is not sufficiently treated. In the present fiscal year, we are planning to investigate the present situation of care system for CLP patients to assess the necessary supports for those countries in south east Asia.

Report

Leader Ichiro Takahashi, Kyushu Univerisity
Researcher Kazuaki Nonaka, Yoshihide Mori, Naoto Haruyama, Haruyoshi Yamaza, Fumie Terao, (Kyushu Univeristy)
Term April 2013 - March 2014
Achievements Outline

 Because the inborn specific abnormality that the phenotype appears in a face and the oral cavity affects chewing, speech, breathing as well as swallowing function, a life support function of the patient. The specific and strange feature of craniofacial anomaly in the face affects a socio-psychological activity leading the reduction of patients’ quality of life remarkably. In this study, we elucidate mechanism of the outbreak of various kinds of inborn abnormality to show the phenotype in face, oral cavity including a cleft lip and/or cleft palate and aim at developing the oral cavity function foundation therapy that we applied a bone reproduction therapy. We have held a seminar and research meeting to establish close relationship among the researchers.
 We have held a seminar to introduce our research achievement and future prospects in the craniofacial biology research and regenerative research during USJI week in September 2013, and the meeting with researchers in the National Institute of Dental and Craniofacial Research/National Institutes of Health, DHHS, USA.

Activity Contents

USJI seminar:
Venue: Board Room, The Embassy Row Hotel, Washington DC,
Date: Monday September 10, 2012,
Event title: Craniofacial Translational Research Based on Molecular Craniofacial Developmental Research
Operating Adviser, USJI Ichiro Takahashi, Kyushu University,
Speakers:Kazuaki Nonaka, Kyushu University Faculty of Dental Science; Dr. Lillian Shum, Chief, NIHDCR/NIH; Haruyoshi Yamaza, Kyushu University Faculty of Dental Science

Publications
1. Cho A, Haruyama N, Hall B, Danton MJS, Zhang L, Arany P, Mooney DJ, Harichane Y,Goldberg M, Gibson CW, Kulkarni AB. : TGF-ß regulates enamel mineralization and maturation through KLK4 expression. PLoS One. 2013 Nov 20;8(11): e82267.

2. Aukkarasongsup P, Haruyama N,Matsumoto T, Shiga M, Moriyama K. : Periostin inhibits hypoxia-induced apoptosis in human periodontal ligament cells via TGF-β signaling. Biochem Biophys Res Commun. 2013 Nov; 441(1): 126-132

3. Makino Y, Yamaza H, Akiyama K, Ma L, Hoshino Y, Nonaka K, Terada Y, Kukita T, Shi S, Yamaza T. Immune therapeutic potential of stem cells from human supernumerary teeth. J Dent Res. 2013 Jul;92(7):609-15.

Relative URL(s)

http://www.us-jpri.org/en/week/sep2013#event5

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